Composite Biological Neurofunction Index

Getting Started

Overview

Indices

Inflammation

Muscle

Bone and mineral

Glucose and insulin

Lipids

Nerve and blood vessel

Oxidative stress and fibrosis

Kidney and protein

Cartilage

Cartilage oligomeric matrix protein

The CBNI sums five domains of nerve function into one score. It uses 11 biomarkers. A higher score means more of the panel sits outside its healthy range, with the most weight on the domains that matter most for this index.

See Indices for how every index is calculated.

Domains

Domain	Biomarkers	αd
Neuroinflammatory Activation (NIA)	hs-CRP, NLR, IL-6	3
Muscle Damage & Matrix Remodeling (MDMR)	CK-MM, Aldolase A, MMP-9	2
Oxidative Stress & Cellular Damage (OSCD)	MDA	6
Neurotrophic Regulation (NTR)	BDNF, NGF	1
Neuroglial Activation (NGA)	Substance P, GFAP	2

αd is the fixed priority of each domain in this index.

Example

These are the results of one example patient, worked through step by step.

Biomarker Z-scores

Each result becomes a Z-score: (value − mean) / SD, with the mean and SD taken from the healthy range.

Neuroinflammatory Activation (NIA)

Biomarker	Healthy range	Mean	SD	Direction	Value	Z	\|Z\|
hs-CRP	0.2–3.0 mg·L⁻¹	1.6	0.7	↑ Bad	3.5	2.71	2.71
NLR	1.0–3.0 ratio	2	0.5	↑ Bad	3.2	2.40	2.40
IL-6	0.5–7.0 pg·mL⁻¹	3.75	1.63	↑ Bad	9.8	3.71	3.71

Muscle Damage & Matrix Remodeling (MDMR)

Biomarker	Healthy range	Mean	SD	Direction	Value	Z	\|Z\|
CK-MM	50–170 U·L⁻¹	110	30	↑ Bad	190	2.67	2.67
Aldolase A	1.2–7.5 U·L⁻¹	4.35	1.58	↑ Bad	8.5	2.63	2.63
MMP-9	20–140 ng·mL⁻¹	80	30	↑ Bad	155.8	2.53	2.53

Oxidative Stress & Cellular Damage (OSCD)

Biomarker	Healthy range	Mean	SD	Direction	Value	Z	\|Z\|
MDA	1.0–3.5 µmol·L⁻¹	2.25	0.63	↑ Bad	4.6	3.73	3.73

Neurotrophic Regulation (NTR)

Biomarker	Healthy range	Mean	SD	Direction	Value	Z	\|Z\|
BDNF	15–40 ng·mL⁻¹	27.5	6.25	↓ Bad	12.8	-2.35	2.35
NGF	20–80 pg·mL⁻¹	50	15	↓ Bad	18.8	-2.08	2.08

Neuroglial Activation (NGA)

Biomarker	Healthy range	Mean	SD	Direction	Value	Z	\|Z\|
Substance P	30–200 pg·mL⁻¹	115	42.5	↑ Bad	225.6	2.60	2.60
GFAP	20–120 pg·mL⁻¹	70	25	↑ Bad	125.7	2.23	2.23

Domain scores

Domain	Mean \|Z\|d	Wd	Mean \|Z\|d × Wd	αd	Score
NIA	2.94	0.21	0.62	3	1.87
MDMR	2.61	0.19	0.49	2	0.98
OSCD	3.73	0.27	1.00	6	6.00
NTR	2.22	0.16	0.35	1	0.35
NGA	2.42	0.17	0.42	2	0.84
Total	13.91	1.00	2.88		10.04

The example patient's CBNI is 10.04.

Oxidative Stress & Cellular Damage adds the most to the score (6.00 of 10.04).

Notes

The mean and SD come from the healthy range, so a result inside the range has a |Z| of 2 or less.
The score has no fixed upper limit. Compare it over time for the same person, not between indices.
This page is general information, not medical advice. Discuss results with a clinician.