Composite Biological Musculoskeletal Index

Getting Started

Overview

Indices

Inflammation

Muscle

Bone and mineral

Glucose and insulin

Lipids

Nerve and blood vessel

Oxidative stress and fibrosis

Kidney and protein

Cartilage

Cartilage oligomeric matrix protein

The CBMI sums five domains of musculoskeletal risk into one score. It uses 21 biomarkers. A higher score means more of the panel sits outside its healthy range, with the most weight on the domains that matter most for this index.

See Indices for how every index is calculated.

Domains

Domain	Biomarkers	αd
Inflammatory Risk (IR)	hs-CRP, NLR, IL-6	2
Muscle-Cartilage Degeneration Risk (MCDR)	CK-MM, Aldolase A, IGF-1, Myostatin, CTX-II	2
Bone Turnover Risk (BTR)	PTH, Ca/P ratio, Vitamin D, Osteocalcin, PINP	1
Cardiometabolic Risk (CMR)	HbA1c, TC, LDL-C, HDL-C	6
Neurovascular Function Risk (NVFR)	BDNF, VEGF, NOx	1

αd is the fixed priority of each domain in this index.

Example

These are the results of one example patient, worked through step by step.

Biomarker Z-scores

Each result becomes a Z-score: (value − mean) / SD, with the mean and SD taken from the healthy range.

Inflammatory Risk (IR)

Biomarker	Healthy range	Mean	SD	Direction	Value	Z	\|Z\|
hs-CRP	0.2–3.0 mg·L⁻¹	1.6	0.7	↑ Bad	3.5	2.71	2.71
NLR	1.0–3.0 ratio	2	0.5	↑ Bad	3.2	2.40	2.40
IL-6	0.5–7.0 pg·mL⁻¹	3.75	1.63	↑ Bad	9.8	3.71	3.71

Muscle-Cartilage Degeneration Risk (MCDR)

Biomarker	Healthy range	Mean	SD	Direction	Value	Z	\|Z\|
CK-MM	50–170 U·L⁻¹	110	30	↑ Bad	190	2.67	2.67
Aldolase A	1.2–7.5 U·L⁻¹	4.35	1.58	↑ Bad	8.5	2.63	2.63
IGF-1	90–360 ng·mL⁻¹	225	67.5	↓ Bad	82.8	-2.11	2.11
Myostatin	2–12 ng·mL⁻¹	7	2.5	↑ Bad	18.3	4.52	4.52
CTX-II	120–450 pg·mL⁻¹	285	82.5	↑ Bad	510.7	2.74	2.74

Bone Turnover Risk (BTR)

Biomarker	Healthy range	Mean	SD	Direction	Value	Z	\|Z\|
PTH	15–65 pg·mL⁻¹	40	12.5	↑ Bad	75.3	2.82	2.82
Ca/P ratio	2.0–2.8 ratio	2.4	0.2	Normal best	2.9	2.50	2.50
Vitamin D	30–100 ng·mL⁻¹	65	17.5	↓ Bad	25.4	-2.26	2.26
Osteocalcin	11–43 ng·mL⁻¹	27	8	↓ Bad	8.9	-2.26	2.26
PINP	20–80 ng·mL⁻¹	50	15	↓ Bad	9.7	-2.69	2.69

Cardiometabolic Risk (CMR)

Biomarker	Healthy range	Mean	SD	Direction	Value	Z	\|Z\|
HbA1c	4.0–5.6 %	4.8	0.4	↑ Bad	7.6	7.00	7.00
TC	120–199 mg·dL⁻¹	159.5	19.8	↑ Bad	225.6	3.34	3.34
LDL-C	50–99 mg·dL⁻¹	74.5	12.3	↑ Bad	185.5	9.02	9.02
HDL-C	40–80 mg·dL⁻¹	60	10	↓ Bad	35.7	-2.43	2.43

Neurovascular Function Risk (NVFR)

Biomarker	Healthy range	Mean	SD	Direction	Value	Z	\|Z\|
BDNF	15–40 ng·mL⁻¹	27.5	6.25	↓ Bad	12.8	-2.35	2.35
VEGF	30–250 pg·mL⁻¹	140	55	Context	305.6	3.01	3.01
NOx	20–60 µmol·L⁻¹	40	10	↓ Bad	18.9	-2.11	2.11

Domain scores

Domain	Mean \|Z\|d	Wd	Mean \|Z\|d × Wd	αd	Score
IR	2.94	0.18	0.53	2	1.06
MCDR	2.93	0.18	0.53	2	1.05
BTR	2.51	0.15	0.39	1	0.39
CMR	5.45	0.33	1.82	6	10.91
NVFR	2.49	0.15	0.38	1	0.38
Total	16.32	1.00	3.64		13.79

The example patient's CBMI is 13.79.

Cardiometabolic Risk adds the most to the score (10.91 of 13.79).

Notes

The mean and SD come from the healthy range, so a result inside the range has a |Z| of 2 or less.
The score has no fixed upper limit. Compare it over time for the same person, not between indices.
This page is general information, not medical advice. Discuss results with a clinician.